BOTH POSITIVE AND NEGATIVE SELECTION PRESSURES CONTRIBUTE TO THE POLYMORPHISM PATTERN OF THE DUPLICATED HUMAN CYP21A2 GENE.

Both positive and negative selection pressures contribute to the polymorphism pattern of the duplicated human CYP21A2 gene.

The human steroid 21-hydroxylase gene (CYP21A2) participates in cortisol and aldosterone biosynthesis, and resides together with its paralogous (duplicated) pseudogene in a multiallelic copy number variation (CNV), called RCCX Self Defense CNV.Concerted evolution caused by non-allelic gene conversion has been described in great ape CYP21 genes, and

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